yk11

Description: YK-11 is a novel, potent, synthetic, steroidal selective androgen receptor modulator (SARM) that acts as a partial agonist of androgen receptor with osteogenic activity. YK11 activates AR without the N/C interaction. The induction of key myogenic regulatory factors (MRFs), such as myogenic differentiation factor (MyoD), myogenic factor 5 (Myf5) and myogenin, was more significant in the presence of YK11 than in the presence of DHT. YK11 treatment of C2C12 cells, but not DHT, induced the expression of follistatin (Fst), and the YK11-mediated myogenic differentiation was reversed by anti-Fst antibody. These results suggest that the induction of Fst is important for the anabolic effect of YK11. It is a gene-selective partial agonist of the androgen receptor (AR) and does not induce the physical interaction between the NTD/AF1 and LBD/AF2 (known as the N/C interaction), which is required for full transactivation of the AR.

References: Biol Pharm Bull. 2013; 36(9):1460-5.