r-skf-38393a

Description: R(+)-SKF-38393A (the R-isomer of SKF-3839A) is a novel potent and selective dopamine D1 receptor agonist with IC50 of 110 nM, the (+)-enantiomer is the active isomer. Agonism of the D1DR by SKF 38393 is correlated to induced desynchronization of electroencephalographic activity in rats. SKF 38393 also demonstrated agonism of the serotonin SR-2C (5-HT1C receptor). SKF 38393 HCl is an activator of D5DR. In locally anesthetized, artificially respired, gallamine-treated rats, i.v. administration of SKF 38393 significantly altered dopamine cell activity. In these rats, firing rate increases and decreases were also observed.

References: Proc Natl Acad Sci U S A. 1995 Mar 28; 92(7):2446-50; Eur J Pharmacol. 2007 Dec 22; 577(1-3):71-7.

Related CAS#: 62717-42-4 (HCl salt); 67287-49-4 (free base); 20012-10-6 (HBr salt); 62751-59-1 (R-isomer)