tenovin-6-hcl

Description: Tenovin-6 is an analog of tenovin-1 with more water-soluble and it inhibits the protein deacetylase activities of SIRT1, SIRT2 and SIRT3 with IC50 value of 21 uM, 10 uM, and 67 uM, respectively. It has been identified that?the cytotoxic effects of?tenovin-6 may occur through the dysregulation of autophagy rather?than induction of apoptosis in chronic lymphocytic leukemia cells. Sir2p homologs could be targets?for tenovin-6 in mammalian cells. Tenovin-6 decreases purified human SirT1 peptide deacetylase activity in vitro with an IC50 of 21 mM and human SirT2 activity with an IC50 of 10 mM.

Reference: Cancer Cell. 2008 May; 13(5):454-63.

Related CAS#: 1011557-82-6 (free base)