lomitapide

InvivoChem Cat #:V3504CAS #:182431-12-5 (free base); 202914-84-9 (mesylate)Purity >=98%

Description: Lomitapide (also known as AEGR-733 and BMS-201038) is a novel and potent inhibitor of microsomal triglyceride-transfer protein (MTP) with IC50 of 8 nM in vitro. Lomitapid is a novel agent for the treatment of homozygous familial hypercholesterolemia. Lomitapide is an orally active inhibitor of microsomal triglyceride transfer protein that is indicated as an adjunct to a low-fat diet and other lipid-lowering treatments, including LDL apheresis where available for the reduction of LDL-C, total cholesterol, apolipoprotein B, and non-high-density lipoprotein cholesterol in adult patients with HoFH.

References: Am J Health Syst Pharm. 2014 Jun 15; 71(12):1001-8.

-20C for 3 years in powder form

Synonym: BMS 201038; BMS-201038; BMS201038; BMS 201038-01; AEGR 733; AEGR733; AEGR-733; Lomitapide mesylate. Brand name: Juxtapid; Lojuxta.
Chemical Name: N-(2, 2, 2-trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)-[1, 1'-biphenyl]-2-carboxamido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide
InChi Key: MBBCVAKAJPKAKM-UHFFFAOYSA-N
InChi Code: InChI=1S/C39H37F6N3O2/c40-38(41, 42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43, 44)45/h1-6, 9-18, 28H, 7-8, 19-25H2, (H, 46, 50)(H, 47, 49)
SMILES Code: O=C(NCC(F)(F)F)C1(C2=C(C=CC=C2)C3=C1C=CC=C3)CCCCN4CCC(CC4)NC(C5=CC=CC=C5C6=CC=C(C=C6)C(F)(F)F)=O