bay-59-3074

Description: Bay 59-3074 is a novel, potent, orally active and selective cannabinoid CB1/CB2 receptor partial agonist with Ki values of 48.3 and 45.5 nM at human CB1 and CB2 receptors respectively. BAY-59-3074 has potential analgesic properties. It displays anti-hyperalgesic and antiallodynic properties in rat models of chronic neuropathic and inflammatory pain. It is concluded that BAY 59-3074 may offer a valuable therapeutic approach to treat diverse chronic pain conditions.

References: Eur J Pharmacol. 2004 Nov 28; 505(1-3):127-33; J Pharmacol Exp Ther. 2004 Aug; 310(2):620-32.

Chemical Name: 1-Butanesulfonic acid, 4, 4, 4-trifluoro-, 3-(2-cyano-3-(trifluoromethyl)phenoxy)phenyl ester;

SMILES Code: O=S(CCCC(F)(F)F)(OC1=CC=CC(OC2=CC=CC(C(F)(F)F)=C2C#N)=C1)=O