tenofovir-hydrate

Description: Tenofovirhydrate (formerly also known as GS-1278; PMPA; TDF) is an approved anti-HIVdrug that blocks reverse transcriptase and hepatitis B virus infections.Tenofovir is an antiretroviral medication used to prevent and treatHIV/AIDS and to treat chronic hepatitis B. Tenofovir reduces the viralcytopathic effect of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) with EC50 of1.15 ug/mL, 1.12 ug/mL and 1.05 ug/mL in MT-4 cells. Tenofovir alsoreduces the viral cytopathic effect of SIV(mac251) , SIV(B670), SHIV(89.6) and SHIV(RTSHIV). Tenofovir is the active substance oftenofovir disoproxil which is a prodrug that is used because of itsbetter absorption in the gut.

References: Antivir Ther. 2004 Feb; 9(1):57-65; Clin Microbiol Rev. 2003 Oct; 16(4):569-96.

Related CAS#: 147127-20-6(Tenofovir); 202138-50-9 (fumarate); 206184-49-8 (hydrate); 206184-49-8(hydrate); 1571075-19-8 (aspartate); 201341-05-1 Tenofovir dsoproxil); 1236287-04-9 (Tenofovir maleate); 1392275-56-7 (Tenofovir alafenamidehemifumarate); 379270-38-9 (Tenofovir alafenamide fumarate); 1464851-21-5 (Z)-9-Propenyladenine; (Z)-Mutagenic Impurity of TenofovirDisoproxil; 1446486-33-4 9-Propenyladenine; Mutagenic Impurity ofTenofovir Disoproxil; Tenofovir Impurity 2; 1276030-80-8(Tenofovir disoproxil maleate) 1453166-76-1 (Tenofovir disoproxilphosphate) 1637632-97-3 (Tenofovir disoproxil succinate)