bafilomycin-b1

Description: Bafilomycin B1 is a naturally occuring macrolide antibiotic agent extracted from Streptomyces sp, it inhibits Gram-positive bacteria and fungi, and acts as an inhibitor of K+-dependent ATPase of E. coli. It is an analog of Bafilomycin A which is a novel, potent and selective inhibitor of vacuolar H+-ATPase (V-ATPases) with IC50 of 0.44 NM. It is a macrolide antibiotic isolated from the Streptomyces species. The inhibitory effect of bafilomycin A1 on vacuolar ATPases was determined by testing its influence on H+-pumping activity. H+ translocation was completely inhibited by 10 nM bafilomycin A1. Other study has shown that bafilomycin A1 strongly inhibited the pit-forming activity of osteoclasts. The subcellular localization of V-ATPase in osteoclasts was been treated with or without bafilomycin A1 by immunoelectron microscopy. Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice. Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways.

References: Bowman EJ, et al. Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proc Natl Acad Sci U S A. 1988 Nov; 85(21):7972-6; Comp Biochem Physiol A Mol Integr Physiol. 2004 Dec; 139(4):425-32; J Bone Miner Res. 1994 Oct; 9(10): 1575-82.

Related CAS #: 88899-56-3 (Bafilomycin B1); 88899-55-(Bafilomycin A1)

Publications Citing Use of InvivoChem Bafilomycin: Eur J Med Chem. 2020 May 5; 199:112377