InvivoChem Cat #:V2880CAS #:1351522-04-7 Purity >=98%Description: AC710 is a potent, orally bioactive, and selective inhibitor of PDGFR (platelet-derived growth factor receptor) family kinase with Kd values of 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRalpha and PDGFRbeta, respectively. As a PDGFR inhibitor, AC710 has potential anticancer activity. Results from a mouse tumor xenograft, a collagen-induced arthritis model, and a 7 day rat in vivo tolerability study culminated in the selection of AC710 as a preclinical development candidate.
References: ACS Med Chem Lett. 2012 Sep 24; 3(12):997-1002
Related CAS#: 1351522-04-7 (free base); 1351522-05-8 (mesylate)