atazanavir

Description: Atazanavir (also called Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir acts by inhibiting HIV protease with Ki of 2.66 nM in a cell-free assay. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus. Atazanavir is distinguished from other PIs in that it can be given once-daily and has lesser effects on the patient's lipid profile. Like other protease inhibitors, it is used only in combination with other HIV medications.

References: Antimicrob Agents Chemother. 2000 Aug; 44(8):2093-9; Cancer Res. 2007 Nov 15; 67(22):10920-8.

Related CAS#: 1192224-24-0 (Atazanavir metabolite); 229975-97-7 (sulfate)

Latazanavir, Zrivada, Reyataz, BMS-232632; BMS232632; BMS 232632; Atazanavir;

Chemical Name: methyl N-[(2S)-1-[2-[(2S, 3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3, 3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[(4-pyridin-2-ylphenyl)methyl]hydrazinyl]-3, 3-dimethyl-1-oxobutan-2-yl]carbamate

Exact Mass: 704.38975