mepenzolate-bromide

Description: Mepenzolate Bromide is a muscarinic antagonist (Kis = 0.68 and 2.6 nM for human M2 and M3 receptors, respectively) used to treat gastrointestinal disorders. It decreases the severity of elastase-induced airspace enlargement and respiratory dysfunction.

References: Yamashita Y, Tanaka K, Asano T, Yamakawa N, Kobayashi D, Ishihara T, Hanaya K, Shoji M, Sugai T, Wada M, Mashimo T, Fukunishi Y, Mizushima T. Synthesis andbiological comparison of enantiomers of mepenzolate bromide, a muscarinicreceptor antagonist with bronchodilatory and anti-inflammatory activities. BioorgMed Chem. 2014 Jul 1; 22(13):3488-97. doi: 10.1016/j.bmc.2014.04.029. Epub 2014Apr 30. PubMed PMID: 24844758.