jnj303

Description: JNJ303 is a potent and specific inhibitor of heteromeric Kv7.1/KCNE1 channel complexes in a concentration- and time-dependent manner. It is a potent IKs blocker with an IC50 value of 64 nM. JNJ 303 does not have any effects on other cardiac channels at concentrations of 3.3 uM for INa, Ica, Ito, and IKr. JNJ 303 induces QT-prolongations and causes unprovoked torsades de pointes (TdP).

References: Altomare C, Pianezzi E, Cervio E, Bolis S, Biemmi V, Benzoni P, Camici GG, Moccetti T, Barile L, Vassalli G. Human-induced pluripotent stem cell-derived cardiomyocytes from cardiac progenitor cells: effects of selective ion channel blockade. Europace. 2016 Dec; 18(suppl 4):iv67-iv76.