jbir22

Description: JBIR-22 is a novel, potent and naturally occuring inhibitor for protein?protein interaction of the homodimer of proteasome assembly factor 3. It is identified from a natural product library using a protein fragment complementation assay (PCA) with monomeric Kusabira-Green fluorescent protein (mKG) in vitroProteasome assembling chaperone (PAC) 3 acts as a homodimer and plays an important role in proteasome formation.

References: Izumikawa M, Hashimoto J, Hirokawa T, Sugimoto S, Kato T, Takagi M, Shin-Ya K. JBIR-22, an inhibitor for protein-protein interaction of the homodimer of proteasome assembly factor 3. J Nat Prod. 2010 Apr 23; 73(4):628-31. doi: 10.1021/np900788e. PubMed PMID: 20180542.