clorsulon

Description: Clorsulon (also known as L631529; MK401) is an antihelminthic agent that is used in the treatment of Fasciola hepatica infections in calves and sheep. Clorsulon acts as a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. Clorsulon (a single dose of 15 mg/kg) is effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep.

References: J Med Chem. 1977 Sep; 20(9):1225-7; Mol Biochem Parasitol. 1982 Mar; 5(3):133-45; Parasitol Res. 2004 Feb; 92(3):232-41.