InvivoChem Cat #:V1936CAS #:104987-12-4Purity >=98%Description: Ascomycin (also known as FK520, FR 900520, Immunomycin), a natural product isolated from Streptomyces, is an ethyl analog of tacrolimus (FK506) and a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant. Ascomycin suppresses immune response in vitro with IC50 of 0.55 nM for mouse mixed lymphocyte. Ascomycin inhibits calcineurin phosphatase with IC50 of 49 nM through formation of an FKBP12-FK520-calcineurin ternary complex.
References: J Antibiot (Tokyo). 1988 Nov; 41(11):1592-601; J Pharmacol Exp Ther. 2002 Sep; 302(3):1278-85.
Related CAS #: 104987-11-3 (tacrolimus free base); 109581-93-3 (tacrolimus hydrate); 11011-38-4 (Ascomycin)