imidapril-hcl

Description: Imidapril HCl (TA-6366) is a potent angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, it is used as an antihypertensive drug and for the treatment of chronic heart failure. As a prodrug, imidapril is converted by hydrolysis in the liver into its active form imidaprilat. Imidaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Imidaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.

References: J Cardiovasc Pharmacol. 2014 Jun; 63(6):528-32.

Related CAS #: 89396-94-1 (HCl) 89371-37-9 (free)