mebendazole

Description: Mebendazole is an Antihelminthic. Mebendazole is a benzimidazole that acts by interfering with carbohydrate metabolism and inhibiting polymerization of microtubules. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake. This results in a depletion of glycogen stores and leads to reduced formation of ATP required for survival and reproduction of the helminth.

References: Speich B, Moser W, Ali SM, Ame SM, Albonico M, Hattendorf J, Keiser J.Efficacy and reinfection with soil-transmitted helminths 18-weeks post-treatmentwith albendazole-ivermectin, albendazole-mebendazole, albendazole-oxantel pamoateand mebendazole. Parasit Vectors. 2016 Mar 2; 9(1):123. doi:10.1186/s13071-016-1406-8. PubMed PMID: 26935065; PubMed Central PMCID:PMC4776366.