jnj-40355003

Description: JNJ-40355003 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor. JNJ-40355003 elevates the plasma levels of three fatty anandamide, oleoyl ethanolamide, and palmitoyl ethanolamide, in the rat, dog, and cynomolgous monkey.

References: Keith JM, Apodaca R, Tichenor M, Xiao W, Jones W, Pierce J, Seierstad M, Palmer J, Webb M, Karbarz M, Scott B, Wilson S, Luo L, Wennerholm M, Chang L, Brown S, Rizzolio M, Rynberg R, Chaplan S, Breitenbucher JG. Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate. ACS Med Chem Lett. 2012 Aug 22; 3(10):823-7. doi: 10.1021/ml300186g. eCollection 2012 Oct 11. PubMed PMID: 24900385; PubMed Central PMCID: PMC4025847.