ciclopirox-ethanolamine

Description: Ciclopirox ethanolamine (also known as Ciclopirox olamine, HOE 296) is a novel, investigational, synthetic, potent and broad-spectrum antifungal agent working as an iron chelator and used as an antifungal agent for topical dermatologic treatment of superficial mycoses. It is currently being investigated as an alternative treatment to ketoconazole for seborrhoeic dermatitis as it suppresses growth of the yeast Malassezia furfur.It acts by inhibiting the membrane transfer system by interrupting the Na+ K+ ATPase. Ciclopirox ethanolamine suppresses many clinically relevant dermatophytes, yeasts, and molds, including the frequently azole-resistant Candida species Candida glabrata, and Candida guilliermondii. Moreover, Ciclopirox has been proved to inhibit a wide range of bacteria in humans, including many gram(+) and gram (-) species pathogenic bacteria.

References: Antimicrob Agents Chemother. 2003 Jun; 47(6):1805-17; Antimicrob Agents Chemother. 2009 Jun; 53(6):2654-6.

Related CAS #: 29342-05-0 (Ciclopirox free); 30652-11-0 (Deferiprone)