trandolapril

Description: Trandolapril (RU-44570), an oral and nonsulfhydryl prodrug that has to be hydrolysed to the active diacid Trandolaprilat, is a potent ACE inhibitor used to treat high blood pressure. It acts by competitive inhibition of angiotensin converting enzyme (ACE), a key enzyme in the renin-angiotensin system which plays an important role in regulating blood pressure.

References: PetersDC, et al. Trandolapril. An update of its pharmacology and therapeuticuse in cardiovascular disorders. Drugs. 1998 Nov; 56(5):871-93.; Cohen V, Jellinek SP, Fancher L, Sangwan G, Wakslak M, Marquart E, Farahani C. Tarka (trandolapril/verapamil hydrochloride extended-release) overdose. J Emerg Med. 2011 Mar; 40(3):291-5. doi: 10.1016/j.jemermed.2008.10.015. Epub 2009 Feb 26. Review. PubMed PMID: 19249183.