InvivoChem Cat #:V16568CAS #:64872-76-0Purity >=98%Description: Butoconazole (RS-35887) is a synthetic imidazole analog with fungistatic/antifungal properties. It is an effective therapy for vulvovaginal candidiasis for women who prefer solid-type vaginal preparations. Butoconazole interferes with steroid biosynthesis by inhibiting the conversion of lanosterol to ergosterol, thereby changing the fungal cell membrane lipid composition. This alters cell permeability and leads to growth inhibition.
References: AnikST, et al. Extreme vertexes design in formulation development:solubility of butoconazole nitrate in a multicomponent system. J PharmSci. 1981; 70(8):897-900.; Jia MM, Zhou Y, He XM, Wu YL, Li HQ, Chen H, Li WY. Development of a liquid chromatography-tandem mass spectrometry method for determination of butoconazole nitrate in human plasma and its application to a pharmacokinetic study. J Huazhong Univ Sci Technolog Med Sci. 2014 Jun; 34(3):431-6.
Related CAS#: 64872-76-0 (free); 64872-77-1 (nitrate)