bvt-2733

Description: BVT-2733 is a selective 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitor, which attenuates obesity and inflammation in diet-induced obese mice. BVT-2733 protects osteoblasts against endogenous glucocorticoid induced dysfunction. BVT-2733 exhibits an anti-inflammatory effect on CIA. This protective effect is, at least partly, mediated by inhibition of the NF-kappaB and NLRP1 inflammasome signaling pathways. 11beta-Hydroxysteroid dehydrogenase 1 (11beta-HSD1) plays an important role in inflammation. 11beta-HSD1 inhibition may represent a potential therapeutic target for RA patients.

References: Zhang L, Dong Y, Zou F, Wu M, Fan C, Ding Y. 11beta-Hydroxysteroid dehydrogenase 1 inhibition attenuates collagen-induced arthritis. Int Immunopharmacol. 2013 Nov; 17(3):489-94. doi: 10.1016/j.intimp.2013.07.015. Epub 2013 Aug 11. PubMed PMID: 23938253.