vidarabine-phosphate

Description: Vidarabine phosphate is an adenosine monophosphate analogue in which ribose is replaced by an arabinose moiety. It is the monophosphate ester of Vidarabine with antiviral and possibly antineoplastic properties.Vidarabine (Ara-A) is an approved antiviral drug that interfers with the synthesis of viral DNA, and is used to treat herpes simplex and varicella zoster viruses. Vidarabine and Acyclovir have a synergistic effect on wild type . Vidarabine is capable of inhibiting acyclovir-resistant/TK-deficient mutants of HSV and VZV, because it is phosphorylated to its active vidarabine–triphosphate form by cellular kinases and is not dependent for its activation on the viral TK.

References: Antiviral Res. 2006 Nov; 72(2):157-61; Antivir Chem Chemother. 2004 Sep; 15(5):281-5.

Related CAS#: 29984-33-6 (phosphate); 53910-25-1 (Pentostatin); 5536-17-4 (free base); 24356-66-9 (hydrate)