InvivoChem Cat #:V1145CAS #:63-92-3Purity >=98%Description: Phenoxybenzamine HCl (formerly NSC-37448; NSC37448; Dibenzyline, NCI-C01661, NCIC01661; NCI-c01661), the hydrochloride salt of Phenoxybenzamine, is a potent, non-specific, irreversible alpha-adrenergic receptor antagonist with antihypertensive effects. It inhibits alpha-adrenergic receptor with an IC50 of 550 nM. Phenoxybenzamine has been used in the treatment of hypertension, and specifically that caused by pheochromocytoma. It has a slower onset and a longer-lasting effect compared with other a-blockers. It was also the first alpha blocker to be used for treatment of benign prostatic hyperplasia, although it is rarely used today.
Description: References: Br J Urol. 1978 Dec; 50(7):551-4
References: Related CAS #: 63-92-3 (HCl) 59-96-1 (free base)