dizocilpine-maleate-[-mk-801-maleate]

Description: (-)-Dizocilpine Maleate also known as (-)-MK-801; MK801; MK 801, the maleate salt of dizocilpine, is a novel, potent, selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist with potential to treat a wide range of neurodegenerative conditions or disorders in which NMDA receptors play an important role. Dizocilpine inhibits NMDA with a Ki of 30.5 nM, and shows potent anti-convulsant, anti-anxiolytic and sympathomimetic activities. MK 801 can penetrate into the central nervous system. In the in vitro assay, MK 801 binds to rat cerebral cortical membrane with high affinity in a saturable manner.

References: Proc Natl Acad Sci U S A. 1986 Sep; 83(18):7104-8; J Neurosurg Anesthesiol. 2006 Oct; 18(4):240-6.

Related CAS#: 77086-22-7 (+)-MK-801; 77086-21-6 (free base)