akba

Description: AKBA, an active triterpenoid isolated from Boswellia serrate, is an antiangiogenic and neuroprotective agent as well as a novel Nrf2 activator. It reduces the impact of proliferative retinopathies, protecting neurons against ischemic injury involving the Nrf2/HO-1 pathway. It selectively inhibits 5-lipoxygenase (IC50 = 1.5 uM) in an enzyme-directed, nonredox, and noncompetitive manner.2 3-acetyl-11-keto-beta-Boswellic acid and other members of the boswellic acid family have been studied for potential use in the control of inflammatory diseases, including arthritis and cancer.

References: J Agric Food Chem. 2017 Dec 7. doi: 10.1021/acs.jafc.7b04203.