tianeptine-sodium

Description: Tianeptine sodium (Stablon, Coaxil, Tianeurax, Tatinol, Salymbra), the sodium salt of tianeptine and an atypical antidepressant, is a potent and selective serotonin reuptake enhancer (SSRE) used primarily for the treatment of major depressive disorders. It may also be used to treat other indications such as asthma or irritable bowel syndrome. Chemically it is a tricyclic antidepressant (TCA), but it has different pharmacological properties than typical TCAs as recent research suggests that tianeptine produces its antidepressant effects through indirect alteration of glutamate receptor activity (i.e., AMPA receptors and NMDA receptors) and release of BDNF, in turn affecting neural plasticity.

References: Neuropharmacology. 2006 Jun; 50(7):824-33; Stress. 2006 Mar; 9(1):29-40.

Related CAS #: 72797-41-2 (free acid); 30123-17-2 (sodium)