erastin

Description: Erastin is a cell-permeable small molecule and potent ferroptosis activator by acting on mitochondrial VDAC with potential antineoplastic activity. It exhibits selectivity for tumor cells bearing oncogenic RAS and shows high in vivo antitumor efficacy in mice with HT-29 xenograft. Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i.e. HRAS, KRAS). Ferroptosis is a unique iron-dependent form of nonapoptotic cell death. It is triggered by oncogenic RAS-selective lethal small molecule erastin. Acitvation of ferroptosis lead to nonapoptotic destruction of cancer cells.

References: Cancer Cell. 2003 Mar; 3(3):285-96; Cell. 2012 May 25; 149(5):1060-72.