knk437

Description: KNK437 (KNK-437; KNK 437; Heat Shock Protein Inhibitor I), a benzylidene lactam analog, is a novel and potent pan-HSP (heat shock proteins) inhibitor with potential antineoplastic activity. KNK-437 inhibited the acquisition of thermotolerance and the induction of various HSPs such as HSP105, HSP70, and HSP40 in a dose-dependent manner in COLO 320DM (human colon carcinoma) cells.

References: Cancer Res. 2000; 60(11):2942-8; Int J Hyperthermia. 2011; 27(1):63-73; Clin Cancer Res. 2001; 7(1):215-9.

Synonym: KNK437; KNK 437; KNK-437;

Chemical Name: (Z)-3-(benzo[d][1, 3]dioxol-5-ylmethylene)-2-oxopyrrolidine-1-carbaldehyde

InChi Key: NJBBLOIWMSYVCQ-VZTVMPNDSA-N

InChi Code: InChI=1S/C33H41N5O6S2/c1-33(2, 3)37-31(42)26-19-46-20-38(26)32(43)29(40)24(15-21-9-6-5-7-10-21)36-30(41)25(18-45-4)35-28(39)17-44-27-12-8-11-22-16-34-14-13-23(22)27/h5-14, 16, 24-26, 29, 40H, 15, 17-20H2, 1-4H3, (H, 35, 39)(H, 36, 41)(H, 37, 42)/t24-, 25-, 26-, 29-/m0/s1

SMILES Code: O=CN1C(/C(CC1)=C\C2=CC=C(OCO3)C3=C2)=O