mardepodect-pf-2545920

Description: Mardepodect (formerly known as PF-2545920, PF2545920, MP10; MP-10) is a novel, potent and selective PDE10A (phosphodiesterase) inhibitor with antipsychotic activity. It inhibits PDE10A with an IC50 of 0.37 nM, and shows > 1000-fold selectivity for PDE10A over other isoforms of PDE. It is potentially useful for the treatment of schizophrenia.

References: J Pharmacol Exp Ther. 2009 Nov; 331(2):574-90; J Med Chem. 2009 Aug 27; 52(16):5188-96.

Related CAS: 1292799-56-4

Chemical Name: 2-(4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxymethyl)quinoline

InChi Key: AZEXWHKOMMASPA-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H20N4O/c1-29-16-23(18-12-14-26-15-13-18)25(28-29)20-7-10-22(11-8-20)30-17-21-9-6-19-4-2-3-5-24(19)27-21/h2-16H, 17H2, 1H3

SMILES Code: CN1N=C(C2=CC=C(OCC3=NC4=CC=CC=C4C=C3)C=C2)C(C5=CC=NC=C5)=C1