su6656

Description: SU 6656 (SU-6656) is a novel, potent and selective Src family kinase (Src, Yes, Lyn, and Fyn) inhibitor with potential antineoplastic activity. It inhibits Src, Yes, Lyn, and Fyn with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM respectively. SU6656 modulates CTGF (connective tissue growth factor) expression in an ERK-dependent manner. SU6656 induces caspase-independent cell death in FRO anaplastic thyroid carcinoma cells and therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo. In NIH 3T3 cell, SU6656 inhibits PDGF-/Src-driven mitogenesis and PDGF-stimulated c-Myc induction.

References: Mol Cell Biol. 2000 Dec; 20(23):9018-27; Nicotine Tob Res. 2012 Apr; 14(4):407-14.

SU 6656; SU-6656; SU6656;

Chemical Name: (Z)-N, N-dimethyl-2-oxo-3-((4, 5, 6, 7-tetrahydro-1H-indol-2-yl)methylene)indoline-5-sulfonamide

InChi Key: LOGJQOUIVKBFGH-YBEGLDIGSA-N

InChi Code: InChI=1S/C19H21N3O3S/c1-22(2)26(24, 25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11, 20H, 3-6H2, 1-2H3, (H, 21, 23)/b16-10-

SMILES Code: O=S(C1=CC2=C(NC(/C2=C\C(N3)=CC4=C3CCCC4)=O)C=C1)(N(C)C)=O