pelitinib-ekb-569

Description: Pelitinib (formerly EKB569; WAY-EKB569; WAY-172569), a 3-cyanoquinoline analog, is an irreversible/covalent EGFR inhibitor with potential antineoplastic activity. It inhibits epidermal growth factor receptor-EGFR with an IC50 of 38.5 nM, more selective for inhibiting EGFR over c-Met, Src, erbB-2, Raf, Cdk4.

References: Nat Med. 2000 Sep; 6(9):1024-8; Mol Cancer Ther. 2004 Jan; 3(1):21-7; J Clin Invest. 2006 Feb; 116(2):309-21.

Chemical Name: (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide

InChi Key: WVUNYSQLFKLYNI-AATRIKPKSA-N

InChi Code: InChI=1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8, 10-12, 14H, 4, 9H2, 1-3H3, (H, 28, 29)(H, 30, 32)/b6-5+

SMILES Code: O=C(NC1=C(OCC)C=C2N=CC(C#N)=C(NC3=CC=C(F)C(Cl)=C3)C2=C1)/C=C/CN(C)C