honokiol

Description: Honokiol (also known as NSC 293100) is a naturally-occuring, bioactive, biphenolic phytochemical and an active ingredient of magnolia extract with potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Honokiol is a natural product extracted from the bark or seed cones of the Magnolia tree. Houpu has traditionally been used in Eastern medicine as analgesic and to treat anxiety and mood disorders. In the late 1990s, honokiol saw a revival in interest as a potent and highly tolerable antitumorigenic and neurotrophic compound. Honokiol possesses potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities by targeting a variety of signaling molecules.

References: J Biol Chem. 2003 Sep 12; 278(37):35501-7; Blood. 2005 Sep 1; 106(5):1794-800.

Related CAS: 1620160-42-0 (Honokiol DCA)