InvivoChem Cat #:V0072CAS #:1019206-88-2 Purity >=98%Description: Regorafenib monohydrate (also known as BAY 73-4506 monohydrate), the hydrated form of Regorafenib, is an orally bioavailable multi-kinase inhibitor targeting kinases such as VEGFR1, VEGFR2, VEGFR3, PDGFRbeta, Kit, RET and Raf-1 with IC50 values of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM in cell-free assays, respectively. It has anticancer activity and has been approved by FDA for the treatment of liver cancer.
Description:References: Int J Cancer, 2011, 129(1), 245-255.
References:Related CAS: 835621-07-3 (HCl); 755037-03-7 (free base)