ArtNr |
TMO-T4439-1g |
Hersteller |
TargetMol
|
CAS-Nr. |
28319-77-9 |
Menge |
1g |
Kategorie |
|
Typ |
Molecules |
Specific against |
other |
Purity |
99.00% |
Citations |
Parnetti L, et al. Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation J Neurol Sci. 2007 Jun 15;257(1-2):264-9. |
Smiles |
C[N+](C)(C)CCOP([O-])(=O)OC[C@H](O)CO |
ECLASS 5.1 |
32169090 |
ECLASS 6.1 |
32169090 |
ECLASS 8.0 |
32169090 |
ECLASS 9.0 |
32169090 |
ECLASS 10.0.1 |
32169090 |
ECLASS 10.1 |
32169090 |
ECLASS 11.0 |
32169090 |
UNSPSC |
12000000 |
Alias |
28319-77-9, AChR, Alpha-GPC , Glycerophosphocholine , Glycerophosphorylcholine , Choline Alfoscerate , Choline glycerophosphate , L-α-GPC |
Lieferbar |
|
Short Description |
sn-Glycero-3-phosphocholine is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have a potential for the treatment of Alzheimer's disease and dementia. sn-Glycero-3-phosphocholine rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter. It is a non-prescription drug in most countries due to its Generally Recognised As Safe (GRAS) status [1]. Studies have investigated its efficacy for cognitive disorders including stroke and Alzheimer's disease. An Italian multicentre clinical trial on 2, 044 patients suffering from recent stroke were supplied Glycerylphosphorylcholine in doses of 1, 000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance [2]. |
Shipping |
cool pack |
Storage |
-20° |
Target names or alias |
Alpha-GPC , Glycerophosphocholine , Glycerophosphorylcholine , Choline Alfoscerate , Choline glycerophosphate , L-α-GPC |
Molecular Weight |
257, 22 |
Pathway |
Neuroscience|||Metabolism |
Target |
AChE|||Endogenous Metabolite |
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