Biological Activity |
Perphenazine is a typical antipsychotic drug, inhibits 5-HT2Areceptor, Alpha-1A adrenergic receptor, Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor, with Ki values of 5.6, 10, 0.765/0.13, 3.4, and 8 nM, respectively. IC50 & Target: Ki: 5.6 nM (Ki, 5-HT2A) 10 nM (Ki, alpha1A), 0.765/0.13 nM (Ki, D2/D3), 3.4 nM (Ki, D2L receptor), 8 nM (Ki, H1)[1]. |