Lexacalcitol

131875-08-6

460.69

10 mM in DMSO

Vitamin D Related

Lexacalcitol (KH1060), a vitamin D analog, is potent regulators of cell growth and immune responses. Lexacalcitol can be used for the research of graft rejection, psoriasis, cancer and auto-immune diseases^[1][2]. In Vitro: Lexacalcitol inhibits cell proliferation by 50% at 10^-12 M (14, 000 times more active than la, 25(OH)₂D₃) in human histiocytic lymphoma cell line U 937^[1].
Lexacalcitol inhibits interleukin-1-induced mouse thymocyte proliferation by 50% at 3x10^-16 M , allogeneic stimulation of mouse spleen lymphocytes at 5x10^-15 M^[1].
In Vivo: Lexacalcitol (0.5 mg/kg/2 days; i.p.) in combination with cyclosporin A (CyA) can prevent autoimmune destruction of syngeneic islet grafts in spontaneously diabetic NOD recipients^[2].