(3S,5S)-Atorvastatin

501121-34-2

558.64

DMSO : 125 mg/mL (223.76 mM; Need ultrasonic)

Metabolic Enzyme/Protease

(3S, 5S)-Atorvastatin is a inactive enantiomer of Atorvastatin. (3S, 5S)-Atorvastatin can activate pregnane X receptor (PXR). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids^[1][2]. IC50 & Target: Pregnane X receptor (PXR)^[1] In Vitro: Atorvastatin and its inactive enantiomer (3S, 5S)-Atorvastatin increases CYP2B and CYP3A mRNA content with equal ability^[1].
(3S, 5S)-Atorvastatin in 100 uM concentrations induces luciferase activity with an EC₅₀ of 12.4 uM^[2].
Addition of (3S, 5S)-Atorvastatin to the 2-formylphenylboronic acid (FPBA)/l-tryptophanol mixture induces an intensity enhancement of l-tryptophanol florescence^[3].