PC945

1931946-73-4

682.73

10 mM in DMSO

Anti-infection; Metabolic Enzyme/Protease

PC945, a potent, long-acting antifungal triazole, possesses activity against a broad range of both azole-susceptible and azole-resistant strains of Aspergillus fumigatus. PC945 is also a potent, tightly binding inhibitor of A. fumigatus sterol 14alpha-demethylase activity, CYP51A and CYP51B, with IC₅₀s of 0.23 uM and 0.22 uM, respectively^[1][2]. In Vitro: PC945 is a triazole antifungal designed for administration via inhalation^[1].
PC945 exhibits the most potent antifungal activity on azole-susceptible strain NCPF2010 with the MIC value of 0.063?ug/mL^[2]. In Vivo: PC945 (0.56-14 ug/mouse; intranasal; daily for 7 days) substantially inhibits the incidence of rolling behavior^[1].