PTP1B-IN-9

145888-79-5

413.12

DMSO : 5 mg/mL (12.10 mM; Need ultrasonic)

Metabolic Enzyme/Protease

PTP1B-IN-9 is a ubiquitin-proteasome system (UPS)-stressor. PTP1B-IN-9 inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activites. PTP1B-IN-9 triggers a ubiquitin-proteasome-system (UPS)-stress response without affecting 20S proteasome catalytic activities. Anticancer activity^[1]. In Vitro: PTP1B-IN-9 (0-30 uM; 48 hours) treatment produces a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively^[1].
PTP1B-IN-9 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC₅₀ value of 2 uM^[1].