Rosmanol

80225-53-2

346.42

DMSO : 150 mg/mL (433.00 mM; Need ultrasonic)

Others

Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect. In Vitro: Rosmanol exhibits the strongest inhibition on cell viability with IC₅₀ approximately 42 uM. Rosmanol might suppress cancer cell proliferation or induce cancer cell undergoing apoptosis that lead to cell growth-inhibition. With 50 uM of Rosmanol treatment, the percentage of COLO 205 cells undergoing apoptosis increase dramatically from 9 h (29%) to 24 h (51%). Within 24 h of treatment with 50 uM Rosmanol, COLO 205 cells exhibit significant morphological changes and chromosomal condensation, which is indicative of apoptotic cell death^[1]. Carnosol is a lipid protector against attack by O₂^[2].