Ro15-4513

91917-65-6

326.31

10 mM in DMSO

Neuronal Signaling; Membrane Transporter/Ion Channel

Ro15-4513, imidazobenzodiazepinone derivative, is a partial inverse agonist of benzodiazepine receptor (BZR)^[1]. Ro15-4513 is a potent ethanol antagonist^[2]. Ro15-4513 has anti-anxiety effect^[3]. IC50 & Target: BZR^[1]; ethanol^[2]; In Vitro: Ro15-4513 usually acts as a partial inverse agonist at GABA_A receptors, except an agonist for alpha4 and alpha6 subunit-containing ones^[3]. In Vivo: Ro 15-4513 (i.p.; 3?mg/kg; 10?min before being tested) completely inhibits the ethanol-induced (1.8?g/kg) reduction in total locomotor activity and partly the reduction in rearing^[2].
Ro 15-4513 (i.p.; 3?mg/kg; 15?min before administration of 1.5?g/kg ethanol) reverses ethanol-induced sedation in GABA_A receptor delta subunit-deficient mice^[2].