Ceefourin 1

315702-40-0

294.42

DMSO : 125 mg/mL (ultrasonic)

Others

Ceefourin 1 is a potent and highly selective multidrug resistance protein 4 (MRP4) inhibitor. Ceefourin 1 inhibits transport of a broad range of MRP4 substrates, yet is highly selective for MRP4 over other ABC transporters. Ceefourin 1 is a benzothiazol and primarily as a chemosensitizer for high-risk neuroblastoma^[1][2]. IC50 & Target: MRP4^[1] In Vitro: Ceefourin 1 are highly selective for MRP4 over other ABC transporters, including P-glycoprotein (P-gp), ABCG2 (Breast Cancer Resistance Protein; BCRP) and MRP1 (ABCC1). Ceefourin 1 has limited off-target effects and high stability^[1].
Ceefourin 1 (100 nM-100 uM) has low cellular toxicity (IC₅₀>50) in two normal (HSF, MRC5), seven neuroblastoma (BE(2)-C, IMR-32, LAN-1, IMR-32, SK-N-SH, NBL-WN, SHEP) and four other human cancer cell lines (HEPG2, LNCap, SJ-G2, MCF7)^[1].
Ceefourin 1 has an IC₅₀ of 2.5 uM in HEK293 cell. Ceefourin 1 blocks D-luciferin efflux with an IC₅₀ of 1.5 uM^[1].