Radicicol

Radicicol is a macrocyclic antifungal antibiotic that inhibits protein tyrosine kinase. It binds to a highly conserved pocket in the Hsp90 (heat shock protein 90) chaperone protein and inhibit the intrinsic ATPase activity of Hsp90.
Radicicol induces the differentiation of HL-60 cells into macrophages, blocking cell cycle at G1 and G2. It suppresses NIH 3T3 cell transformation by diverse oncogenes such as  src,   ras  and  mos  and also suppresses the expression of mitogen-inducible cyclooxygenase-2. As a cell differentiation modulator, radicicol has anti-angiogenic activity  in vivo, inhibiting the proliferation of and plasminogen activator production by vascular endothelial cells.
 

364, 78

99% (HPLC)

White powder

C₁₈H₁₇ClO₆