Pepstatin Ammonium

ArtNr	HY-P0018B-25mg
Hersteller	MedChem Express
Menge	25 mg
Quantity options	10 mg 25 mg 50 mg 5 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.76
Citations	[1]Umezawa H, et al. Pepstatin, a new pepsin inhibitor produced by Actinomycetes. J Antibiot (Tokyo). 1970 May;23(5):259-62.\|[2]Seelmeier S, et al. Human immunodeficiency virus has an aspartic-type protease that can be inhibited by pepstatin A. Proc Natl Acad Sci U S A. 1988 Sep;85(18):6612-6. Biol Pharm Bull. 2022 Apr 1;45(4):438-445. ACS Nano. 2024 Jan 23;18(3):2162-2183. Int J Antimicrob Agents. 2019 Dec;54(6):814-819. ACS Nano. 2024 Jul 2;18(26):16790-16807. Adv Sci (Weinh). 2022 Oct 10;e2203831. Adv Sci (Weinh). 2023 Oct;10(28):e2302130. Adv Sci (Weinh). 2025 Aug 7:e09208. Arch Biochem Biophys. 2023 Jul 15:743:109646. Autophagy. 2025 Jul;21(7):1591-1607. Biochem Bioph Res Co. 2020 Sep 10;530(1):292-300. Biochem Biophys Res Commun. 2024 Jun 15:725:150271. bioRxiv. 2023 Nov 5. bioRxiv. 2024 November 14. Br J Pharmacol. 2025 May;182(10):2310-2331. Cancer Lett. 2022 Jun 1:535:215629. Carbohydr Polym. 2023 Nov 1:319:121208. Cell Death Dis. 2022 Dec 16;13(12):1048. Cell Rep. 2021 Nov 2;37(5):109931. Cell Rep. 2025 Jan 15;44(1):115219. Cell. 2025 Oct 24:S0092-8674(25)01131-6. Environ Sci Technol. 2017 Dec 5;51(23):13938-13948. Eur J Pharmacol. 2022 Apr 5:920:174823. FASEB J. 2022 Jan;36(1):e22121. Free Radic Biol Med. 2025 Aug 1:235:95-108. Immunotargets Ther. 2025 Mar 4:14:151-173. Int J Oncol. 2019 Jul;55(1):331-339. J Virol. 2021 Nov 23;95(24):e0153721. J Virol. 2023 Nov 30;97(11):e0107523. Maastricht University. 2025. Mol Med Rep. 2019 Jan;19(1):41-50. Mol Pharm. 2024 May 9. Nat Commun. 2025 Apr 2;16(1):3153. Nat Commun. 2025 Jul 16;16(1):6551. Nat Commun. 2025 Mar 11;16(1):2412. Nat Commun. 2025 Nov 19;16(1):10181. Nature. 2024 Aug;632(8025):686-694. Nature. 2024 Aug;632(8026):930-937. Pharmaceuticals (Basel). 2022 Dec 3;15(12):1509. Pharmacol Res. 2022 Jan:175:105985. PLoS Genet. 2025 Jul 10;21(7):e1011794. PLoS Pathog. 2024 Feb 14;20(2):e1011981. PLoS Pathog. 2025 Oct 17;21(10):e1013581. Protein Sci. 2024 Dec;33(12):e5225. Redox Biol. 2024 Apr:70:103064. Sci Adv. 2022 Nov 11;8(45):eabn6579. SSRN. 2023 Apr 10. STAR Protoc. 2025 Jul 18;6(3):103963. Structure. 2025 Sep 5. Theranostics. 2024 Jul 22;14(11):4481-4498. Toxicol Appl Pharmacol. 2018 Oct 1;356:159-171.
Smiles	CC(C[C@H](NC([C@@H](NC([C@@H](NC(CC(C)C)=O)C(C)C)=O)C(C)C)=O)[C@@H](O)CC(N[C@@H](C)C(N[C@@H](CC(C)C)[C@@H](O)CC(O)=O)=O)=O)C.N
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Pepstatin A Ammonium
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Peptides
Manufacturer - Applications	COVID-19-anti-virus
Manufacturer - Category	Peptides; Reference compound / Active compounds; Natural Products
Manufacturer - Targets	Autophagy; HIV Protease
Shipping Temperature	Blue Ice
Storage Conditions	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Molecular Weight	702.92
Product Description	Pepstatin (Pepstatin A) Ammonium is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Ammonium also inhibits HIV protease[1][2].
Manufacturer - Research Area	Infection; Inflammation/Immunology
Solubility	DMSO : 25 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Autophagy; Metabolic Enzyme/Protease
Clinical information	No Development Reported
UNSPSC Code	12352209

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