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Gamma-Mangostin

Gamma-Mangostin

ArtNr	HY-N1957-10mg
Hersteller	MedChem Express
CAS-Nr.	31271-07-5
Menge	10 mg
Quantity options	10mM/1mL 10 mg 1 mg 20 mg 5 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.90
Formula	C23H24O6
Citations	[1]Chairungsrilerd N, et al. Gamma-mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):25-31.<br/>[2]Yokoyama T, et al. Discovery of γ-Mangostin as an Amyloidogenesis Inhibitor. Sci Rep. 2015 Aug 27;5:13570.<br/>[3]Husen S A, et al. Hepatoprotective Effect of Gamma-mangostin for Amelioration of Impaired Liver Structure and Function in Streptozotocin-induced Diabetic Mice. 2018 IOP Conf. Ser.: Earth Environ. Sci. 217 012031<br/>[4]Husen S A, et al. Renal protective effects of gamma-mangostin in streptozotocin-induced diabetic mice[J]. Indian Journal of Forensic Medicine & Toxicology, 2020, 14(3): 1251-1256.<br/>[5]Chen, S P, Lue, et al.Gamma-mangostin of Garcinia mangostana peels ameliorates hyperglycemia in synergism of insulin. The FASEB Journal, 33: 694.11-694.11.
Smiles	O=C1C2=C(OC3=C1C(C/C=C(C)\C)=C(O)C(O)=C3)C=C(O)C(C/C=C(C)\C)=C2O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	γ-Mangostin
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Product Description	Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer[2]. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes[1][2][3][4][5].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Metabolism-protein/nucleotide metabolism
MolecularWeight	396.43
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer; Metabolic Disease; Inflammation/Immunology
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	5-HT Receptor; COX; Transthyretin (TTR)
Manufacturers Target	5-HT Receptor; COX; Transthyretin (TTR)
Isoform	5-HT2 Receptor; COX-2
Manufacturers Pathway	GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Manufacturers Product type	Natural Products

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Menge: 10 mg

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