ArtNr |
HY-N1957-10mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
31271-07-5 |
Menge |
10 mg |
Quantity options |
10mM/1mL
10 mg
1 mg
20 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
99.90 |
Formula |
C23H24O6 |
Citations |
[1]Chairungsrilerd N, et al. Gamma-mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):25-31.<br/>[2]Yokoyama T, et al. Discovery of γ-Mangostin as an Amyloidogenesis Inhibitor. Sci Rep. 2015 Aug 27;5:13570.<br/>[3]Husen S A, et al. Hepatoprotective Effect of Gamma-mangostin for Amelioration of Impaired Liver Structure and Function in Streptozotocin-induced Diabetic Mice. 2018 IOP Conf. Ser.: Earth Environ. Sci. 217 012031<br/>[4]Husen S A, et al. Renal protective effects of gamma-mangostin in streptozotocin-induced diabetic mice[J]. Indian Journal of Forensic Medicine & Toxicology, 2020, 14(3): 1251-1256.<br/>[5]Chen, S P, Lue, et al.Gamma-mangostin of Garcinia mangostana peels ameliorates hyperglycemia in synergism of insulin. The FASEB Journal, 33: 694.11-694.11. |
Smiles |
O=C1C2=C(OC3=C1C(C/C=C(C)\C)=C(O)C(O)=C3)C=C(O)C(C/C=C(C)\C)=C2O |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
γ-Mangostin |
Lieferbar |
|
Product Description |
Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer[2]. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes[1][2][3][4][5]. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
Metabolism-protein/nucleotide metabolism |
MolecularWeight |
396.43 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Cancer; Metabolic Disease; Inflammation/Immunology |
Solubility |
DMSO : 100 mg/mL (ultrasonic) |
Target |
5-HT Receptor; COX; Transthyretin (TTR) |
Manufacturers Target |
5-HT Receptor; COX; Transthyretin (TTR) |
Isoform |
5-HT2 Receptor; COX-2 |
Manufacturers Pathway |
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling |
Manufacturers Product type |
Natural Products |
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