ArtNr |
HY-N1487-10mM |
Hersteller |
MedChem Express
|
CAS-Nr. |
17990-42-0 |
Menge |
10 mM/1 mL |
Quantity options |
10 mM/1 mL
50 mg
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
99.63 |
Formula |
C30H46O3 |
Citations |
[1]Giner-Larza EM et al.Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity.Eur J Pharmacol.Sep 28;428(1):137-43.doi:10.1016/S0014-2999(01)01290-0(2001) [2]Fabio Mengoni.Anti-HIV Activity of Oleanolic Acid on Infected Human Mononuclear Cells.Planta Med 68(2): 111-114.DOI: 10.1055/s-2002-20256(2002) [3]Cristiano S. FUNARI, et al. Oleanonic acid from Lippia lupulina (Verbenaceae).shows strong in vitro antileishmanial and antitrypanosomal activity. Acta Amazonica. 46 (4) .Oct-Dec 2016 [4]Hui Gao, et al. Oleanonic acid ameliorates pressure overload-induced cardiac hypertrophy in rats: The role of PKCζ-NF-κB pathway. Mol Cell Endocrinol. 2018 Jul 15:470:259-268. [5]Liqing Tao, et al. Oleanonic acid ameliorates mutant Aβ precursor protein-induced oxidative stress, autophagy deficits, ferroptosis, mitochondrial damage, and ER stress in vitro. Biochim Biophys Acta Mol Basis Dis. 2024 Dec;1870(8):167459. |
Smiles |
CC1(C)C(CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])CC(C)(C)CC[C@@](C(O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H])=O |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
3-Oxooleanolic acid |
Versandbedingung |
Raumtemperatur |
Lieferbar |
|
Manufacturer - Type |
Natural Products |
Manufacturer - Applications |
Cancer-programmed cell death |
Manufacturer - Targets |
Amyloid-β; Autophagy; Ferroptosis; HIV |
Shipping Temperature |
Room Temperature |
Storage Conditions |
-20°C, 3 years; 4°C, 2 years (Powder) |
Molecular Weight |
454.68 |
Product Description |
Oleanonic acid (3-Oxooleanolic acid) is an orally available triterpene that has anti-inflammatory and insecticidal properties. In vitro, oleanonic acid can improve oxidative stress, autophagy defects, ferroptosis, mitochondrial damage, and endoplasmic reticulum stress induced by Amyloid-β, and in vivo, it can alleviate myocardial hypertrophy in rats[1][2][3][4][5]. |
Manufacturer - Research Area |
Cancer; Infection; Inflammation/Immunology; Neurological Disease |
Solubility |
DMSO : 50 mg/mL (ultrasonic)|H2O : ≥ mg/mL |
Manufacturer - Pathway |
Anti-infection; Apoptosis; Autophagy; Neuronal Signaling |
Isoform |
HIV-1 |
Clinical information |
No Development Reported |
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