ArtNr |
HY-N0904-10mM |
Hersteller |
MedChem Express
|
CAS-Nr. |
39262-14-1 |
Menge |
10 mM/1 mL |
Quantity options |
10 mM/1 mL
10 mg
1 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
99.92 |
Formula |
C36H62O8 |
Citations |
[1]Kim JH, et al. Role of ginsenosides, the main active components of <i>Panax ginseng</i>, in inflammatory responsesand diseases. J Ginseng Res. 2017 Oct;41(4):435-443. [2]Zhang J, et al. Ginsenosides Regulate PXR/NF-κB Signaling and Attenuate Dextran Sulfate Sodium-Induced Colitis. Drug Metab Dispos. 2015 Aug;43(8):1181-9. [3]Liu KK, et al. Ginsenoside compound K suppresses the abnormal activation of T lymphocytes in mice with collagen-induced arthritis. Acta Pharmacol Sin. 2014 May;35(5):599-612. [4]Liu Y, et al. Ginsenoside metabolites, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes. Toxicol Sci. 2006 Jun;91(2):356-64. |
Smiles |
C[C@@]([C@@]12C)(CC[C@@]3([H])C4(C)C)[C@@](C[C@@H](O)[C@]1([H])[C@]([C@@](CC/C=C(C)/C)(C)O[C@@H]([C@@H]([C@@H](O)[C@@H]5O)O)O[C@@H]5CO)([H])CC2)([H])[C@]3(CC[C@@H]4O)C |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
Ginsenoside compound K, Ginsenoside K |
Versandbedingung |
Raumtemperatur |
Lieferbar |
|
Manufacturer - Type |
Natural Products |
Manufacturer - Applications |
COVID-19-immunoregulation |
Manufacturer - Targets |
COX; Cytochrome P450; NO Synthase |
Shipping Temperature |
Room Temperature |
Storage Conditions |
-20°C, 3 years; 4°C, 2 years (Powder) |
Molecular Weight |
622.87 |
Product Description |
Ginsenoside C-K, a bacterial metabolite of G-Rb1, exhibits anti-inflammatory effects by reducing iNOS and COX-2. Ginsenoside C-K exhibits an inhibition against the activity of CYP2C9 and CYP2A6 in human liver microsomes with IC50s of 32.0±3.6 μM and 63.6±4.2 μM, respectively. |
Manufacturer - Research Area |
Inflammation/Immunology |
Solubility |
DMSO : ≥ 100 mg/mL |
Manufacturer - Pathway |
Immunology/Inflammation; Metabolic Enzyme/Protease |
Isoform |
COX-2; CYP2; iNOS |
Clinical information |
No Development Reported |
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