ArtNr |
HY-N0226A-10mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
889665-86-5 |
Menge |
10 mg |
Quantity options |
10mM/1mL
10 mg
50 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
99.02 |
Formula |
C20H18ClNO4 |
Citations |
Molecules. 2024 May 14.<br/>Aging (Albany NY). 2021 Oct 9;13(19):23193-23209.<br/>J Biomol Struct Dyn. 2022 Dec 29;1-38.<br/>J Ethnopharmacol. 2024 Feb 19:117931.<br/>[1]Jung HA, et al. Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids. Biol Pharm Bull. 2009 Aug;32(8):1433-8.<br/>[2]Choi JS, et al. Anti-adipogenic effect of epiberberine is mediated by regulation of the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways. Arch Pharm Res. 2015 Dec;38(12):2153-62.<br/>[3]Ma H, et al. Antihyperglycemia and Antihyperlipidemia Effect of Protoberberine Alkaloids From Rhizoma Coptidis in HepG2 Cell and Diabetic KK-Ay Mice. Drug Dev Res. 2016 Jun;77(4):163-70. |
Smiles |
COC1=C(OC)C=C2C(CC[N+]3=C2C=C(C=C4)C(C5=C4OCO5)=C3)=C1.[Cl-] |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
889665-86-5 |
Lieferbar |
|
Product Description |
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease[1]. Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways[2]. Epiberberine has the potential effect in the research of diabetic disease[3]. |
StorageTemperature |
4°C (Powder, sealed storage, away from moisture) |
Shipping |
Room Temperature |
Manufacturers Applications |
Metabolism-sugar/lipid metabolism |
MolecularWeight |
371.81 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Metabolic Disease; Neurological Disease |
Solubility |
DMSO : 25 mg/mL (ultrasonic) |
Target |
Beta-secretase; Cholinesterase (ChE); Reactive Oxygen Species |
Manufacturers Target |
Beta-secretase; Cholinesterase (ChE); Reactive Oxygen Species |
Isoform |
AChE; BACE1; BChE |
Manufacturers Pathway |
Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB |
Manufacturers Product type |
Natural Products |
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