ArtNr |
HY-N0222-10mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
572-30-5 |
Menge |
10 mg |
Quantity options |
10mM/1mL
10 mg
1 mg
20mg
25 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Specific against |
other |
Purity |
99.48 |
Formula |
C20H18O11 |
Citations |
[1]Vo VA, et al. Avicularin Inhibits Lipopolysaccharide-Induced Inflammatory Response by Suppressing ERK Phosphorylation in RAW 264.7 Macrophages. Biomol Ther (Seoul). 2012 Nov;20(6):532-7.<br>[2]Wang Z, et al. Avicularin ameliorates human hepatocellular carcinoma via the regulation of NF‑κB/COX‑2/PPAR‑γ activities. Mol Med Rep. 2019 Jun;19(6):5417-5423.<br>[3]Ko Fujimori, et al. Avicularin, a plant flavonoid, suppresses lipid accumulation through repression of C/EBPα-activated GLUT4-mediated glucose uptake in 3T3-L1 cells. J Agric Food Chem. 2013 May 29;61(21):5139-47. <br>[4]Zi-Ling Zou, et al. Avicularin suppresses cartilage extracellular matrix degradation and inflammation via TRAF6/MAPK activation. Phytomedicine. 2021 Oct;91:153657. <br>[5]Nikita Patil Samant, et al. Avicularin Attenuates Memory Impairment in Rats with Amyloid Beta-Induced Alzheimer's Disease. Neurotox Res. 2022 Feb;40(1):140-153. |
Smiles |
O=C1C(O[C@H]2[C@@H]([C@H]([C@H](CO)O2)O)O)=C(C3=CC=C(O)C(O)=C3)OC4=CC(O)=CC(O)=C14 |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
572-30-5 |
Lieferbar |
|
Product Description |
Avicularin is an orally active flavonoid. Avicularin inhibits NF-κB (p65), COX-2 and PPAR-γ activities. Avicularin has anti-inflammatory, anti-infectious anti-allergic, anti-oxidant, hepatoprotective, and anti-tumor activities[1][3]. |
StorageTemperature |
4°C (Powder, protect from light) |
Shipping |
Room Temperature |
Manufacturers Applications |
Cancer-programmed cell death |
MolecularWeight |
434.35 |
Clinical_Information |
No Development Reported |
Manufacturers Research Area |
Cancer; Infection; Inflammation/Immunology; Neurological Disease |
Solubility |
DMSO : 100 mg/mL (ultrasonic) |
Manufacturers Target |
Apoptosis; COX; ERK; GLUT; NF-κB; PPAR |
Isoform |
COX-2; GLUT4; PPARγ |
Pathway |
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor |
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