ArtNr |
HY-N0102-50mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
961-29-5 |
Menge |
50 mg |
Quantity options |
100 mg
10mM/1mL
10 mg
200 mg
50 mg
5 mg
|
Kategorie |
|
Typ |
Inhibitors |
Clon |
N/A |
Specific against |
other |
Purity |
98.17 |
Formula |
C15H12O4 |
Citations |
[1]Aida K, et al. Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix. Planta Med. 1990 Jun;56(3):254-8.<br/>[2]Sato Y, et al. Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. Biol Pharm Bull. 2007 Jan;30(1):145-9.<br/>[3]Zhang X. Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway. Mediators Inflamm. 2013;2013:390890.<br/>[4]Chen X, et al. Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. J Mol Med (Berl). 2012 Nov;90(11):1311-9.<br/>[5]Traboulsi H, et al. The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection. Antimicrob Agents Chemother. 2015 Oct;59(10):6317-27. |
Smiles |
O=C(C1=CC=C(O)C=C1O)/C=C/C2=CC=C(O)C=C2 |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
GU17; ISL; Isoliquiritigen; SJ000286237 |
Lieferbar |
|
Product Description |
Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC50 of 24.7 μM. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
Cancer-Kinase/protease |
MolecularWeight |
256.25 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Cancer; Infection; Inflammation/Immunology |
Solubility |
DMSO : ≥ 100 mg/mL|Ethanol : 100 mg/mL (ultrasonic) |
Target |
Aldose Reductase; Apoptosis; Autophagy; Influenza Virus |
Manufacturers Target |
Aldose Reductase; Apoptosis; Autophagy; Influenza Virus |
Manufacturers Pathway |
Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease |
Manufacturers Product type |
Natural Products |
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